Drug - Drug Interaction Study Between Quinine Sulfate and Theophylline
Status:
Completed
Trial end date:
2007-09-01
Target enrollment:
Participant gender:
Summary
In a prior in vitro study using human hepatocytes quinine was shown to induce the activity of
Cytochrome p450 CYP 1A2. The present study will evaluate the extent to which quinine
sulfate-related induction of this enzyme effects the pharmacokinetics of theophylline, a
sensitive probe drug for the activity of CYP 1A2. It will also evaluate the effect of
single-dose theophylline on the pharmacokinetics of steady-state quinine sulfate.