Drug-Drug Interaction Between Colchicine and Ritonavir
Status:
Completed
Trial end date:
2008-08-01
Target enrollment:
Participant gender:
Summary
Ritonavir is a potent inhibitor of CYP3A4, one of the enzymes responsible for the metabolism
of colchicine. This study will evaluate the effect of multiple doses of ritonavir on the
pharmacokinetic profile of a single 0.6 mg dose of colchicine. A secondary objective is to
evaluate the safety and tolerability of this regimen in healthy volunteers. All study
subjects will be monitored for adverse events throughout the study period.