This study will investigate the potential therapeutic benefit of perioperative dronabinol use
in patients undergoing unilateral total knee arthroplasty (TKA). With current advanced
regional anesthetic techniques and peripheral nerve blocks, pain is generally well controlled
following TKA on post operative day (POD) 1. There is a rebound pain that exists, however, on
post operative discharge day 2 (POD2) when these blocks are no longer effective. We aim to
study a potential reduction in opioid consumption on POD2 with perioperative dronabinol use
in TKA patients