Overview

Doxycycline vs. Macrolide for MRMP (DOMINO)

Status:
NOT_YET_RECRUITING
Trial end date:
2029-02-28
Target enrollment:
Participant gender:
Summary
The goal of this clinical trial is to learn if doxycycline works to treat pneumonia in children. It focuses on children with Mycoplasma pneumoniae infection that may not respond to standard medicines. The main questions it aims to answer are: * Does doxycycline stop fevers faster than azithromycin? * Is doxycycline safe for children, specifically regarding tooth color changes? Researchers will compare doxycycline to azithromycin to see if doxycycline works better to treat this type of pneumonia. Participants will: * Take either doxycycline or azithromycin by mouth for 7 to 14 days. * Check their body temperature to see when their fever goes away. * Visit the hospital to check for any medical problems. * Have their teeth checked for color changes 28 days after starting the medicine.
Phase:
PHASE4
Details
Lead Sponsor:
Young June Choe
Collaborators:
DT&CRO
Korea Disease Control and Prevention Agency
Korea National Institute of Health
Korea Society of Pediatric Infectious Diseases
Treatments:
Azithromycin
Doxycycline