Doxycycline in Treating Patients With Chronic Rhinosinusitis With Nasal Polyps
Status:
Terminated
Trial end date:
2016-08-01
Target enrollment:
Participant gender:
Summary
The Department of Otolaryngology at Mount Sinai is looking for adults with sinus disease with
polyps, otherwise called chronic rhinosinusitis with nasal polyps (CRSwNP). Patients may be
eligible to enroll in a study offering a cutting-edge therapy to help reduce symptoms and
avoid surgery. The treatment combines an antibiotic (doxycycline) with oral steroids. Oral
steroids are the mainstay of medical management for patients with CRSwNP. However, recent
studies have shown that doxycycline helps improve symptoms as well by reducing inflammation
and killing common bacteria that can cause symptoms. This study is the first to evaluate this
combination regimen.