Doxycycline for Helicobacter Pylori Rescue Treatment
Status:
Recruiting
Trial end date:
2024-12-31
Target enrollment:
Participant gender:
Summary
Current guidelines have recommended classical bismuth-containing quadruple therapy including
proton-pump inhibitor, bismuth, tetracycline, metronidazole as the empirical rescue therapy.
However, tetracycline is clinically unavailable in China and the high frequency of adverse
events of bismuth quadruple therapy often result in poor compliance, which limited the
applicability of this recommendation. This study aimed to compare the efficacy and
tolerability of a 14-day bismuth-containing quadruple rescue therapy in which tetracycline
was replaced by doxycycline.