Doxycycline for Emphysema in People Living With HIV (The DEPTH Trial)
Status:
Not yet recruiting
Trial end date:
2024-06-30
Target enrollment:
Participant gender:
Summary
The purpose of this study is to determine if doxycycline will reduce progression of emphysema
in people living with HIV.
The secondary objectives are to examine the effects of doxycycline on change in quantity of
emphysema, six minute walk distance, patient reported outcomes, ratio of forced expiratory
volume in 1 second and forced vital capacity. Secondary objectives will also describe the
safety and tolerability of doxycycline and determine if doxycycline is associated with
development of antibiotic-resistant bacterial infections.
Phase:
Phase 2
Details
Lead Sponsor:
Weill Medical College of Cornell University
Collaborators:
National Heart, Lung, and Blood Institute (NHLBI) University of California, Los Angeles University of Iowa University of Michigan