Doxycycline Prophylaxis at Vacuum Aspiration Trial
Status:
Completed
Trial end date:
2008-03-01
Target enrollment:
Participant gender:
Summary
This study is a randomized, double-blinded, controlled trial comparing two regimens of
doxycycline for the prevention of infection after surgical abortion. One thousand women
undergoing surgical abortion in the first trimester will be enrolled from the clinic at Tu Du
Hospital, Ho Chi Minh City, Vietnam. The standard regimen has been 100 mg twice daily for 5
days after the abortion. Subjects will be randomized to the standard regimen or to take 200
mg doxycycline pre-operatively. Subjects found to have a positive Chlamydia EIA test will
receive a 7-day course of doxycycline regardless of study group. Subjects will complete
questionnaires of symptoms, including nausea and emesis in the recovery room after the
procedure and at a single follow-up visit two weeks later. The primary outcome will be
infection after abortion, defined below. Analyses will be performed including and excluding
Chlamydia-positive subjects. Secondary outcomes will be the proportion with nausea, emesis,
and other side-effects.