Doxycycline PEP for Prevention of Sexually Transmitted Infections Among Kenyan Women Using HIV PrEP
Status:
Recruiting
Trial end date:
2024-06-30
Target enrollment:
Participant gender:
Summary
This is a randomized clinical trial of doxycycline post-exposure prophylaxis (dPEP) to reduce
bacterial STIs among Kenyan women taking pre-exposure prophylaxis (PrEP). The overarching
goal is to assess the effectiveness of dPEP on incidence of STIs while also balancing
acceptability, cost, and impact on tetracycline resistance to inform public health policy.
Participants will be randomized to receive dPEP and standard of care or the standard of care
only. Questionnaires, focus group discussions, SMS, and in-depth interviews will be used to
study acceptability and changes sexual behavior due to dPEP.
Phase:
Phase 4
Details
Lead Sponsor:
University of Washington
Collaborators:
Kenya Medical Research Institute Kenya National AIDS & STI Control Programme National Institute of Allergy and Infectious Diseases (NIAID) University of California, San Francisco