The goal of this project is to collect data regarding the ability of various oral doses of
doxycycline to penetrate mucosal tissues in men and women to inform the combination of
doxycycline with antiretrovirals (ARVs) for the development of single-dose event-driven
multipurpose prevention strategies to protect against HIV and sexually transmitted infections
(STIs).
This study is of importance in the field of research because it allows the exploration of new
dosing strategies that would permit a single event-driven oral dose of medications that could
provide protection from HIV as well as other STIs.
The study population that this study seeks to enroll are healthy people assigned male or
female sex at birth and not using gender-affirming hormone therapy and are willing to undergo
study procedures.
Recruitment: Both face-to-face and online engagements will be conducted to recruit study
participants. Face-to-face locations include bars and nightclubs, community organizations
serving study populations, sports events, and community venues, and online engagements
include dating sites, social networks, and craigslist, amongst other social medial platforms.