Overview

Doxepin and a Topical Rinse in the Treatment of Acute Oral Mucositis Pain in Patients Receiving Radiotherapy With or Without Chemotherapy

Status:
Completed
Trial end date:
2019-03-15
Target enrollment:
0
Participant gender:
All
Summary
The purpose of this study is to test whether a mouthwash made with a drug called doxepin can reduce the pain caused by mouth sores resulting from radiation therapy. A number of mouth rinse preparations exist for patients with treatment-related oral mucositis pain such as the DLA rinse, an over-the-counter medication. This study will evaluate the effects of doxepin compared to DLA (diphenhydramine, lidocaine and antacids) and placebo.Doxepin is approved by the Food and Drug Administration (FDA) for the treatment of depression, anxiety, long-term pain management, as well as management of rash.
Phase:
Phase 3
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Alliance for Clinical Trials in Oncology
Collaborator:
National Cancer Institute (NCI)
Treatments:
Antacids
Anti-Ulcer Agents
Diphenhydramine
Doxepin
Lidocaine
Promethazine
Criteria
1. Documentation of Disease: Histologic documentation of malignancy currently undergoing
a course of RT (with or without chemotherapy) including the oral cavity and/or
oropharyngeal area to a dose of at least 4500 cGy using more than 5 fractions (i.e.,
stereotactic body radiation therapy [SBRT] is not allowed).

2. Physical exam demonstrating evidence of radiotherapy-related mucositis in the visible
oral cavity and/or oropharynx consistent with mucous membrane toxicity greater than 0
using the Acute Radiation Morbidity Scoring Criteria.

3. At least 4 (out of 10) patient-reported oral pain related to oral mucositis secondary
to RT for which the patient seeks relief, as measured on the Oral Pain Assessment.

Note: The pain score must be at least 4 at the time that the patient starts the first
dose of study medication. The patient may be enrolled to the study if s/he, at times,
has a pain score of at least 4, so long as initiation of study treatment begins when
the pain score is at least 4.

4. Ability to complete questionnaire(s) by themselves or with assistance.

5. No known allergy to diphenhydramine, lidocaine, antacid (aluminum hydroxide, magnesium
hydroxide, and simethicone), doxepin, tricyclic antidepressants, or any known
component of the drug formulation in the testing arms.

6. No use of any anti-arrhythmic medication (except for beta-blockers) including
lidocaine, linezolid, ipratropium, or medications with high anti-cholinergic potency
(including neostigmine, a tricyclic antidepressant or a monoamine oxidase inhibitor)
within 2 weeks prior to registration.

7. No current diagnosed untreated or unresolved oral candidiasis or oral HSV infection.

8. No history of untreated narrow angle glaucoma within 6 weeks prior to registration.

9. No untreated urinary retention within 6 weeks prior to registration.

10. No current use of glutamine or sucralfate powders at the time of registration (no
washout required).

11. No cryotherapy for prophylactic mucosal protection within 6 weeks prior to
registration.

12. Not pregnant, because patients eligible for this study will be receiving radiotherapy,
which has known genotoxic, mutagenic and teratogenic effects. Therefore, for women of
childbearing potential only, a negative pregnancy test done ≤ 28 days prior to
registration is required.

13. Age ≥ 18 years

14. ECOG Performance Status 0, 1, or 2