Overview

Double-dose Rabeprazole Accelerates and Sustains the Control of Symptoms in Patients With NERD

Status:
Withdrawn
Trial end date:
2012-12-01
Target enrollment:
0
Participant gender:
All
Summary
To the best of our knowledge, there has been no randomized controlled trial to compare double dose PPI therapy with standard one dose PPI therapy for NERD patients. Thus, we hypothesize that a double dose PPI would accelerate and sustain the control of symptom in NERD patients.
Phase:
Phase 3
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Inje University
Treatments:
Rabeprazole
Criteria
Inclusion Criteria:

- heartburn and/or reflux at least twice weekly in the absence of visible esophageal
mucosal breaks at endoscopy

Exclusion Criteria:

- pregnancy

- lactation

- Hx of gastric surgery

- Hx of gastric cancer or peptic ulcer

- major medical problems (including CHF, renal failure, COPD, asthma, liver cirrhosis)

- severe systemic illness

- Hx of malignancy, allergy Hx to rabeprazole

- patients who had taken antibiotics

- antisecretory agents including H2-blocker

- PPI within 4 weeks before endoscopy

- current usage of steroids, NSAIDs, aspirin, anticoagulant medication