Dosing Chart for Calculating the First Dose of Doxapram in Premature Infants

• Status: Completed
• Trial end date: 2010-11-01
• Target enrollment: 0
• Participant gender: All

Summary

Doxapram is used to stimulate respiration. For a given dose, the fluctuations in concentrations observed in infants' blood may be wide, leading to a risk of lack of efficacy or of toxic effects. Two factors are linked to these fluctuations: age and gender. The aim of this study is to compare a dosage regimen based only on patient's weight, to another one using a dosing chart taking into account weight, age and gender.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Jean Michel Hascoet; Maternite Regionale Universitaire
• Treatments: Doxapram

Criteria

Inclusion Criteria:

• Premature infants (<37 weeks gestation)

• More than 1 significant Apnea q 8h (> 20 sec or < 20 sec with bradycardia or desaturation)

• Already treated with caffeine

Exclusion Criteria:

• Intubation

• congenital malformation

• symptomatic apnea