Dose-response of Cannabis and Driving

• Status: Recruiting
• Trial end date: 2022-08-31
• Target enrollment: 0
• Participant gender: All

Summary

Epidemiological studies have established a link between collisions while driving and cannabis use. With the changing legal landscape around cannabis, there is much interest in determining per se limits of cannabis while driving. The present study will evaluate driving on a driving simulator after smoking placebo or cannabis with 3 different levels of THC. THC is the active component in cannabis and blood, urine and oral fluid levels of THC will be correlated with driving impairment.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Centre for Addiction and Mental Health

Criteria

Inclusion Criteria:

• Near daily use of cannabis (1-5 days/week) confirmed by self-report and urine screening

• Has held a class G2 or G licence (or equivalent from another jurisdiction) for at least 12 months

• Willing to abstain from using cannabis for 72 hours prior to each practice or test session

• Willing to abstain from alcohol for 48 hours prior to each session, and to abstain from all other drugs not medically required for the duration of the study (beginning 48 hours prior to the practice session)

• Provides written and informed consent

Exclusion Criteria:

• Diagnosis of severe medical or psychiatric condition

• Meets criteria for current or lifetime alcohol or other substance use disorder, except tobacco use disorder and caffeine use disorder

• Regular user of medication that may affect cognitive functioning and/or driver performance

• Family history of schizophrenia or other psychotic disorder

• Pregnant, looking to become pregnant, or breastfeeding