Dose-escalation Study to Assess Selumetinib Safety, Tolerability and PK
Status:
Completed
Trial end date:
2014-05-01
Target enrollment:
Participant gender:
Summary
The purpose of the study is to assess the safety, tolerability and PK of selumetinib
(AZD6244; ARRY-142886) (Hyd-Sulfate) in healthy male Japanese and non-Japanese Asian
volunteers following administration of a single dose. Standard safety assessments including
ECGs, vital signs, blood/urine safety tests, PK samples and monitoring of adverse events and
an optional exploratory pharmacogenetics will be performed.