Epinephrine is the principal physiologic defense against hypoglycemia in type 1 and longer
duration type 2 DM. Despite this, it is unknown how epinephrine regulates in-vivo endothelial
function and atherothrombotic balance in humans. The specific aim of our study will be to
determine the dose response effects of the key ANS counterregulatory hormone epinephrine on
endothelial function, fibrinolytic balance and pro-atherogenic inflammatory mechanisms in
healthy humans.
Phase:
Early Phase 1
Details
Lead Sponsor:
University of Maryland University of Maryland, Baltimore