SONIA 1 is an international, multicentre, randomised, open-label, no-treatment controlled,
parallel group, dose-response study to investigate the effect of once daily nitisinone on
24-hour urinary homogentisic acid excretion in patients with alkaptonuria after 4-weeks
treatment. They study will identify the optimal dose to decrease urine homogentisic acid to
near normal levels.
Phase:
Phase 2
Details
Lead Sponsor:
University of Liverpool
Collaborators:
Liverpool University Hospitals NHS Foundation Trust Royal Liverpool and Broadgreen University Hospitals NHS Trust