Dose Response Relationship of Oxytocin on Irritability in Youths
Status:
Not yet recruiting
Trial end date:
2023-08-01
Target enrollment:
Participant gender:
Summary
The proposed study is a randomized, double-blind proof of concept (PoC) study on the neural
impact of intranasal oxytocin (OXT) administration for adolescents (age 14 to 18),
demonstrating a clinically significant level of irritability as defined by a score of ≥4 on
the Affective Reactivity Index (ARI). Planned enrollment is 80 subjects over 3 years.
Phase:
Phase 1/Phase 2
Details
Lead Sponsor:
University of Nebraska
Collaborators:
National Institute of Mental Health (NIMH) National Institutes of Health (NIH)