Dose Optimization by Pharmacokinetic/Pharmacodynamic of Antibiotics to Improve Clinical Outcome of Carbapenem Resistant Klebsiella Pneumoniae Bloodstream Infections in Critically Ill Patients at Phramongkutklao Hospital

• Status: Recruiting
• Trial end date: 2024-06-30

Summary

The patients who infected with Carbapenem resistant Klebsiella pneumoniae were high mortality rate. Appropriate antibiotics therapy adjusted by Pharmacokinetic/Pharmacodynamic plays an important role in determining outcomes in Critically ill patients. Consequently, standard antibiotics dose may not be adequate to achieve pharmacokinetic/pharmacodynamic target in Critically ill patients. The purpose of this study is to compare the clinical outcomes between the critically ill patients who received antibiotics dose adjusted by pharmacokinetic/pharmacodynamic using Monte Carlo simulation and historical critically ill patients who received antibiotics from standard practice.

• Phase: Phase 4

Details

• Lead Sponsor: Phramongkutklao College of Medicine and Hospital
• Collaborator: Silpakorn University
• Treatments: Amikacin; Anti-Bacterial Agents; Antibiotics, Antitubercular; Avibactam; Ceftazidime; Colistin; Gentamicins; Imipenem; Meropenem; Tigecycline