The purpose of this 8-week, double-blind, placebo-controlled, study is to explore new
treatment options for people with depression who have high inflammation and anhedonia.
Seventy male and female participants with depression, between 25-55 years of age, with higher
levels of inflammation and anhedonia will be randomized to receive L-DOPA or matched placebo
over 8 weeks. Participants will complete lab tests, medical and psychiatric assessments,
motivation and motor tasks, and MRI scans as part of the study. The total length of
participation is approximately 10 to 12 weeks.
Phase:
Phase 4
Details
Lead Sponsor:
Emory University
Collaborator:
National Institute of Mental Health (NIMH)
Treatments:
Carbidopa Carbidopa, levodopa drug combination Levodopa