Dopaminergic Mechanism of Memory Impairment in Parkinson's Disease
Status:
Recruiting
Trial end date:
2021-12-31
Target enrollment:
Participant gender:
Summary
The cognitive impairment of Parkinson's disease is non amnestic, which is characterized by
working memory impairment and executive dysfunction. The current drug therapy (such as
levodopa, dopamine receptor agonists) and surgical treatment (such as deep brain electrical
stimulation, thalamic lesion) not only can not effectively alleviate cognitive impairment,
but also may aggravate cognitive and speech behavior abnormalities. This project will explore
how dopamine regulates temporal working memory in human research by combining drug
intervention, neuroimaging and cognitive tasks.