Dopamine Versus Norepinephrine for the Treatment of Vasopressor Dependent Septic Shock

• Status: Completed
• Trial end date: 2009-08-01
• Target enrollment: 0
• Participant gender: All

Summary

We are performing a prospective, randomized, controlled trial of dopamine versus norepinephrine for septic shock. The trial will enroll patients with suspected or documented site of infection and having 2 out of the three SIRS criteria. Patients will also be receiving standard of care, early-goal directed therapy including but not limited to fluid resuscitation, appropriate and early antibiotics, source control and evaluation for drotrecogin alpha where deemed appropriate, while being supported for septic shock.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Rush University Medical Center
• Treatments: Dopamine; Dopamine Agents; Norepinephrine; Vasoconstrictor Agents

Criteria

Inclusion Criteria:

• Patients are transferred to our medical intensive care unit from the emergency room (ER), general medical floors, and from outside hospitals.

• Patients were eligible if they were greater than 18 years of age

• Presented with a diagnosis of SIRS plus a suspected or documented source of infection.

Exclusion Criteria:

• Patients were not eligible if they were found to have hypovolemic and/or hemorrhagic etiologies of their vasodilatory shock or another etiology of their SIRS.