Domperidone as a Treatment for Dopamine Agonist-induced Peripheral Edema in Patients With Parkinson's Disease
Status:
Terminated
Trial end date:
2008-09-01
Target enrollment:
Participant gender:
Summary
The dopamine agonists, pramipexole (Mirapex) and ropinirole (Requip), are drugs that are used
to treat symptoms of Parkinson's disease. However, these drugs can induce bothersome leg
swelling or edema in about 20 percent of patients. The cause of this edema is unknown but may
be secondary to stimulation of peripheral dopamine receptors in the kidney or blood vessels.
We hypothesise that a peripherally acting dopamine receptor antagonist, will reduce edema in
PD patients. This study will assess the effect of the peripheral acting dopamine D2 receptor
antagonist, domperidone as a potential treatment for dopamine agonist-induced leg swelling.