Does Tranexamic Acid Administration Reduce Blood Loss During Head and Neck Surgery?

• Status: Completed
• Trial end date: 2007-01-01
• Target enrollment: 0
• Participant gender: All

Summary

To Study whether infusion of Tranexamic Acid (a synthetic antifibrinolytic agent) reduces blood loss during head and neck surgery.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Tata Memorial Hospital
• Treatments: Tranexamic Acid

Criteria

Inclusion Criteria:

• All eligible previously untreated patients with resectable squamous cell carcinoma of the oral cavity

• Undergoing composite resection of the mandible along with neck dissection and requiring reconstructive procedures in the form of pedicled flaps.

• Patients who agree to participate by giving informed consent.

Exclusion Criteria:

• Coagulopathy form any cause (Abnormal coagulogram - prothrombin time (PT) > 18 seconds or partial prothrombin time (PTT) > 50 seconds, recent (<5 days) acetylsalicylic acid ingestion, anticoagulant therapy (heparin, 4 hours preoperative or warfarin, 3 days preoperatively).

• Pre-existing renal dysfunction (serum creatinine 200 mmol/L),

• Known allergy to tranexamic acid,

• Peripheral vascular disease.