Does Sleep Quality Change After Switch From Wellbutrin SR to Wellbutrin XL in Patients With Major Depressive Disorder?
Status:
Completed
Trial end date:
2010-01-01
Target enrollment:
Participant gender:
Summary
Wellbutrin (bupropion) is an effective antidepressant (Thase, M 2005). It exists in instant
release (IR), sustained release (SR) and extended release (XL) forms. The IR formulation was
never approved for use in Canada. The XL formulation allows for once daily dosing.
Wellbutrin is both a norepinephrine and dopamine reuptake inhibitor, and as such increases
the synaptic concentration of both neurotransmitters. This adds to its positive effects on
cognition, apathy, tiredness and executive functioning. The increased activation may be also
responsible for some of its side effects such as initial insomnia and reduced sleep
efficiency, especially when taken at night.