Does Single Dose Imipramine Affect the Opening Pressure of the Urethral and Anal Sphincter?
Status:
Completed
Trial end date:
2017-06-21
Target enrollment:
Participant gender:
Summary
A double-blinded, randomized, crossover study in healthy females with placebo and single dose
imipramine 50 mg.
Primary objective: Does imipramine increase the tone of the external urethral sphincter?
Urethral Opening Pressure (UOP) is measured with Urethral Pressure Reflectometry (UPR). UOP
increases correlate with effect in treating stress urinary incontinence. Can imipramine treat
stress urinary incontinence? Secondary objective: Does imipramine increase the tone of the
anal sphincter? The opening pressure is measured with Anal Acoustic Reflectometry (AAR). The
investigators also wish to establish the within-subject standard deviation for AAR to enable
power calculations in future studies.