Does Simvastatin Affect Insulin Sensitivity in Dyslipidemic Type 2 Diabetic Patients?
Status:
Completed
Trial end date:
2005-07-01
Target enrollment:
Participant gender:
Summary
We aimed to address the issue whether statins affect insulin resistance. To this end, we
combined the available state-of-the art technology for detailed assessment of both whole-body
and tissue specific insulin sensitivity in vivo in humans (euglycemic-hyperinsulinemic clamp,
stable isotope [6,6-2H2]glucose dilution technique, proton nuclear magnetic resonance
spectroscopy - 1H MRS - of liver and skeletal muscle). Outcome measures were determined
before and after 8 weeks therapy with 80 mg Simvastatin in hypercholesterolemic patients with
type 2 diabetes.
Phase:
N/A
Details
Lead Sponsor:
Medical University of Vienna
Collaborators:
Austrian Science Fund (FWF) EU grant European Foundation for the Study of Diabetes Merck Sharp & Dohme Corp.