Does Propranolol, a Beta Blocker, Attenuate Stress-Induced Drinking?
Status:
Recruiting
Trial end date:
2026-02-28
Target enrollment:
Participant gender:
Summary
For this protocol, the investigators plan to conduct a pilot study evaluating the effect of
propranolol on alcohol consumption. Using a parallel design, the investigators plan to
randomize 20 non-treatment seeking adults with alcohol use disorders (DSM-5) to propranolol
extended release (160mg/day or placebo; n=10 per cell) to evaluate whether propranolol
reduces alcohol self-administered in the laboratory. Importantly, the investigators will
evaluate whether propranolol counteracts stress-induced effects on alcohol
self-administration. Following titration to steady state medication levels over a 2-week
period, each subject will complete two laboratory sessions consisting of a well validated
method for inducing stress or neutral/relaxing state (order counterbalanced), followed by a
2-hour alcohol self-administration paradigm known to be sensitive to medication effects.
Phase:
Phase 2
Details
Lead Sponsor:
Yale University
Collaborator:
National Institute on Alcohol Abuse and Alcoholism (NIAAA)