Does Progesterone Prevent Very Preterm Delivery in Twin Pregnancies?

• Status: Completed
• Trial end date: 2010-09-01
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of the study is to determine whether a daily dose of 200 mg progesterone administered vaginally from 20-23 to 34 weeks' gestation will reduce the rate of preterm delivery amongst twin pregnancies.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Rigshospitalet, Denmark
• Collaborators: AP Moeller Foundation; The Danish Medical Research Council; The Danish Medical Society in Copenhagen
• Treatments: Progesterone

Criteria

Inclusion Criteria:

• Twin pregnancy

• Informed consent

• 18-23 weeks' gestation

• Participants must be fluent in the language spoken in the respective centres

Exclusion Criteria:

• Age < 18 years

• Known allergy to progesterone or peanuts

• Active thromboembolic disorders or a history of hormone-associated thromboembolic disorders

• Rupture of membranes at the time of inclusion

• Monoamniotic twins

• Pregnancies treated for or with signs of twin-to-twin transfusion syndrome at inclusion

• Multiple pregnancies reduced to twin pregnancies

• Known significant structural or chromosomal fetal abnormality

• Chorionicity not assessed before 15 weeks

• Known or suspected malignancy in genitals or breasts

• Known liver disease