Does Preventive Dexketoprofen Reduce Pain After Orthognathic Surgery
Status:
Completed
Trial end date:
2019-02-01
Target enrollment:
Participant gender:
Summary
Background The purpose of this study was to evaluate the effect of a single-dose intravenous
dexketoprofen administration for preventive analgesia on postoperative pain and reducing
swelling in double jaw surgery.
Material and Methods The authors designed a prospective, randomized, and double-blind cohort
study. Patients who have Class III malocclusion were randomly divided in two groups. 50 mg
intravenous dexketoprofen trometamol were administrated 30 minutes before incision in
treatment group, while intravenous sterile saline was administrated 30 minutes before
incision in placebo group. The primary predictor variable was treatment group. Primary
outcomes were pain, swelling and 24-hour opioid intake. Patient- controlled analgesia with
tramadol was given for management of postoperative pain. Other variables were demographic and
operation related parameters. Visual analogue scale was used to evaluate postoperative pain.
3dMD Face System (3dMD, USA) was used to measure postoperative swelling. Data were analysed
using two independent samples t test and Mann Whitney U test.