Does Oxytocin Alter Tolerance to or Motivation for Alcohol

• Status: Recruiting
• Trial end date: 2022-12-31
• Target enrollment: 0
• Participant gender: All

Summary

This pilot study will seek evidence that oxytocin, compared to placebo, reverses tolerance and alcohol seeking in humans.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Indiana University
• Treatments: Oxytocin

Criteria

Inclusion Criteria:

• Heavy alcohol drinkers.

• Able to understand/complete questionnaires and procedures in English.

• Have venous access sufficient to allow blood sampling.

Exclusion Criteria:

• Latex allergy.

• Nasal condition that compromises delivery and/or absorption of intra-nasal oxytocin

• Pregnant or breast-feeding women.

• Desire to be treated for any substance use disorder or court ordered to not drink alcohol

• Medical disorders or other conditions such as alcohol withdrawal seizures or delirium tremens that may influence study outcome or participant safety.

• Positive urine drug screen for amphetamines/ methamphetamines, barbiturates, benzodiazepines, cocaine, opiates, or phencyclidine if determined by the PI to adversely affect participant safety or data integrity.

• Medications (past 30 days) that could influence participant safety or data integrity (e.g. antidepressants, antipsychotics, benzodiazepines, etc.) as determined by the PI.

• DSM 5 Disorders (other than alcohol) or current/history of neurological disease of cerebral origin, or head injury with > 20 min loss of consciousness, if determined by the PI to affect participant safety or data integrity.

• Positive breath alcohol reading at beginning of the experimental session.

• Actively suicidal (for example, any current suicidal intent, including a plan) or are at serious suicidal risk, by clinical judgment of the PI.

• Any condition for which the PI and investigative team determine it is unsafe or not prudent to enroll a participant.