Does Nightly Dexmedetomidine Improve Sleep and Reduce Delirium in ICU Patients?
Status:
Completed
Trial end date:
2016-12-01
Target enrollment:
Participant gender:
Summary
Specific Aims
1. Establish the feasibility of larger trial by implementing a sleep protocol in the ICU at
2 different sites. Specifically will be estimating the recruitment rates of patients and
the compliance with both interventions.
2. Measure the safety and tolerance of adding night-time sedation with dexmedetomidine
using adverse effects and withdrawal rates as indicators.
3. Measure the effect of nocturnal dexmedetomidine on pertinent clinical outcomes and use
this outcome data to plan a larger, multicenter trial in this area.
The goal of this study is to determine whether a night-time protocol that incorporates a
pharmacologic intervention associated with improved sleep (i.e. dexmedetomidine) will improve
sleep quality and reduce the incidence of delirium and sub-syndromal delirium in critically
ill patients.