Does Intraperitoneal Instillation of Lidocaine at Cesarean Delivery Improve Postoperative Analgesia?
Status:
Completed
Trial end date:
2015-11-01
Target enrollment:
Participant gender:
Summary
The instillation of local anesthetic into the peritoneum has been found to be safe and
effective in reducing postoperative pain and morphine consumption after abdominal surgery. A
review of studies reporting serum levels of local anesthetic after intraperitoneal delivery
found no cases of clinical toxicity in any of the trials. The studies in this meta-analysis
did not include post-cesarean delivery pain and there is a lack of data to support the use of
intraperitoneal local anesthetic after cesarean section.
The purpose of this study is to assess the efficacy of intraperitoneal lidocaine on
postoperative pain scores after cesarean delivery. This study will compare a 20ml solution of
lidocaine (400mg) with epinephrine 5mcg/ml versus normal saline (placebo) instilled into the
peritoneum at the end of surgery in women undergoing cesarean delivery. The investigators
hypothesize that intraperitoneal lidocaine will result in lower pain scores, reduce opioid
consumption and opioid related side effects, and higher maternal satisfaction after cesarean
delivery.
Phase:
N/A
Details
Lead Sponsor:
Samuel Lunenfeld Research Institute, Mount Sinai Hospital