Does Hyaluronic Acid Affect Periodontal Treatment?

• Status: Completed
• Trial end date: 2018-09-30
• Target enrollment: 0
• Participant gender: All

Summary

Objective: The aim of this study is to evaluate the effect of HA as an adjunct to scaling and root planning (SRP) on clinical parameters, periodontal inflamed surface area (PISA) and adenosine deaminase (ADA), catalase (CAT), and glutathione (GSH) levels in gingival crevicular fluid (GCF) in patients with periodontitis.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Yuzuncu Yıl University
• Treatments: Hyaluronic Acid

Criteria

Inclusion Criteria:

• Systemically healthy

• moderate-to-severe periodontitis

• at least five sites with ≥5mm probing depth (PD)

• at least ≥20 teeth

• Stage II-III periodontitis according to the 2017 World Workshop

• Age between18-55

Exclusion Criteria:

• receiving systemic or local antibiotics within the past six months

• prior surgical or non-surgical periodontal treatment within the past six months

• smoking

• pregnancy

• lactation

• age ≤18 years or ≥55 years

• hypertension

• known chronic systemic diseases (i.e., diabetes mellitus, rheumatoid arthritis), - - known hypersensitivity to one of the ingredients of the HA preparation.