Does High-dose Vitamin B3 Supplementation Prevent Major Adverse Kidney Events During Septic Shock?
Status:
Recruiting
Trial end date:
2024-01-01
Target enrollment:
Participant gender:
Summary
Sepsis is the most common cause of acute kidney injury (AKI) in critically ill patients and
is associated with a high mortality rate. Currently there is no available specific treatment
to prevent or treat AKI in this setting. Many experimental and clinical data suggest that
Nicotinamide, a safe and inexpensive vitamin, could be effective to prevent major adverse
kidney events during septic shock. The main objective of the study is to show the superiority
of Nicotinamide supplementation compared to the placebo group, in patients with septic shock
admitted to intensive care. A 15% reduction in the incidence of major renal adverse events at
day 30 is expected in the "Nicotinamide" group.
Phase:
Phase 3
Details
Lead Sponsor:
Centre Hospitalier Universitaire, Amiens
Collaborators:
Centre Hospitalier Arras Centre Hospitalier d'Abbeville Centre Hospitalier de Bethune Centre Hospitalier de Calais Centre Hospitalier de Cherbourg Centre Hospitalier de Dieppe Centre Hospitalier de Laon Centre Hospitalier de Lens Centre Hospitalier de Roubaix Centre Hospitalier de Valenciennes Hôpital Saint Philibert, Lomme Tourcoing Hospital University Hospital, Caen University Hospital, Rouen