Does Duloxetine Reduce Chronic Pain After Total Knee Arthroplasty?
Status:
Unknown status
Trial end date:
2016-12-01
Target enrollment:
Participant gender:
Summary
Range from 24% to 44%, with a prevalence of neuropathic-type pain from 6% to 20%-cause
impairment in quality of life and functional capacity after total knee arthroplasty(TKA).
Duloxetine (cymbalta) is a selective serotonin and nor-epinephrine reuptake inhibitor shown
to be effective in treating chronic pain. Serotonin and norepinephrine in the brain and
spinal cord are believed to both mediate core mood symptoms and help regulate the perception
of pain. Its effects on depression and anxiety symptoms, as well as its effect on pain
perception, may be due to increasing the activity of serotonin and norepinephrine in the
central nervous system. Approved for the acute and maintenance treatment of major depressive
disorder, the acute treatment of generalized anxiety disorder, the management of diabetic
peripheral neuropathic pain and the management of fibromyalgia, all in adults (18+).
Investigators will compare the neuropathic pain following TKA in duloxetine group (n=84) with
those in non-duloxetine group (n=84). Investigators will classify the participants in to 2
groups (duloxetine and non-duloxetine group) randomly, and primarily evaluate the degree of
neuropathic pain using the S-LANSS pain scale (preoperatively and postoperatively 3 and 6
months). All participants will receive postoperative pain control after TKA using the same
pain control regimen except duloxetine.