Does Concurrent Hydrocortisone With Venlafaxine XR Speed Antidepressant Response?

• Status: Completed
• Trial end date: 2006-04-01
• Target enrollment: 0
• Participant gender: All

Summary

The primary purpose of this study is to examine whether IV hydrocortisone can speed up the time required for Venlafaxine XR to work.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Stanford University
• Collaborator: Wyeth is now a wholly owned subsidiary of Pfizer
• Treatments: Antidepressive Agents; Cortisol succinate; Hydrocortisone; Hydrocortisone 17-butyrate 21-propionate; Hydrocortisone acetate; Venlafaxine Hydrochloride

Criteria

Inclusion Criteria::- outpatients at least 18 years of age

• current major depressive episode

• HDRS greater than or equal to 21

• good physical health Exclusion Criteria:- history of sensitivity, intolerance, or non-response to venlafaxine

• history of sensitivity to hydrocortisone

• history of bipolar 1 illness

• meets DSM-IV criteria for a current or past psychotic disorder

• meets DSM-IV criteria for substance abuse or dependence in previous 6 months

• significant imminent suicide risk

• medical condition that would compromise participation in the study

• woman of child bearing potential not using adequate birth control in the opinion of the investigator