Does Additional Use of Preoperative Azithromycin Decrease Posthysterectomy Infections
Status:
Not yet recruiting
Trial end date:
2030-12-01
Target enrollment:
Participant gender:
Summary
During hysterectomy bacteria may enter into the peritoneal cavity through vaginal opening and
contaminate the healing tissues. The risk for deep infection after hysterectomy is about 5%.
By reducing post-hysterectomy infections, it is possible to reduce individual burden of
disease in addition to the direct and indirect financial costs. This study primary aim is to
assess if prophylactic preoperative use of azithromycin in addition to generally used
cefuroxime decreases post-hysterectomy infections as compared to cefuroxime only prophylaxis
during 30 days after hysterectomy. Secondary aim is to assess if there is change in
post-hysterectomy superficial infections, urinary tract infections, or post-operative fever
between the cohorts and to report possible side-effects of the used antibiotics. In addition,
the study finds out a possible role of bacterial vaginosis and microbiome n post-hysterectomy
infections.
Phase:
N/A
Details
Lead Sponsor:
Helsinki University Central Hospital
Collaborators:
Kuopio University Hospital Oulu University Hospital Tampere University Hospital University of Turku