Does Adding Oral Contraceptives to Fluoxetine Improve the Management of Premenstrual Syndrome?
Status:
Unknown status
Trial end date:
2017-09-01
Target enrollment:
Participant gender:
Summary
Three hundred women with severe premenstrual syndrome will be divided into 3 groups using
computer generated random numbers. Group 1 will receiveCombined oral contraceptives (COC)
containing drospirenone (drospirenone 3mg+Ethinylestradiol 0.03mg) daily for 21 days starting
from the 3rd day of menstruation in addition to oral fluoxetine 20 mg daily. Group 2 will
receive fluoxetine 20 mg daily in addition to an oral placebo similar to COC daily for 21
days starting from the 3rd day of menstruation.Group 3 will receive oral placebo similar to
COC daily for 21 days starting from the 3rd day of menstruation in addition to a daily oral
placebo similar in size, color and structure to fluoxetine.