Do Flavors Increase the Addiction Potential of Nicotine?
Status:
Completed
Trial end date:
2021-08-31
Target enrollment:
Participant gender:
Summary
The FDA has concluded that flavors (e.g. menthol) are associated with greater addiction
potential in tobacco cigarettes (Gottlieb March 13, 2019). Whether the same is true for
e-cigarettes and non-menthol flavors is unclear and our study should help answer this
question.
Our major hypothesis is that the pharmacological effect of nicotine to induce addiction will
be greater with use of a preferred e-cigarette flavor than with use of a non-preferred
flavor. The pharmacological effect will be measured by how much a larger nicotine dose
increases addiction potential compared to a smaller dose.