Do Corticosteroid Injections During Total Knee Replacement Improve Early Clinical Results?

• Status: Completed
• Trial end date: 2008-02-01
• Target enrollment: 0
• Participant gender: All

Summary

Prior to surgery, a pharmacist will randomly assign participating patients to one of two groups. One group will get an injection in the knee during surgery that contains medications to limit pain and an antibiotic. A second group will get an injection in the knee during surgery that contains the same pain medications and antibiotic along with a corticosteroid to control inflammation. Corticosteroids are anti-inflammatory medications, not to be confused with muscle-building anabolic steroids you may have heard about in the news. Each patient will have an equal chance of being in either of the two groups. This study will test the safety and efficacy of methylprednisolone acetate in the treatment of pain and inflammation following total knee replacement.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: New Lexington Clinic
• Collaborator: St. Joseph's Health Care London
• Treatments: Bupivacaine; Cefuroxime; Cefuroxime axetil; Clonidine; Epinephrine; Epinephryl borate; Methylprednisolone; Methylprednisolone Acetate; Methylprednisolone Hemisuccinate; Morphine; Prednisolone; Prednisolone acetate; Prednisolone hemisuccinate; Prednisolone phosphate; Racepinephrine

Criteria

Inclusion Criteria:

• Between ages of 18 and 95

• Has elected to undergo total knee replacement

Exclusion Criteria:

• Allergy to any of the medications used in the protocol

• History of kidney disease

• Rheumatoid arthritis

• Any systemic conditions associated with chronic pain

• History of deep knee sepsis in the affected extremity

• Unable to understand the questions used to obtain the Knee Society Score

• Minors and prisoners will be excluded from the study