Do Corticosteroid Injections During Total Knee Replacement Improve Early Clinical Results?
Status:
Completed
Trial end date:
2008-02-01
Target enrollment:
Participant gender:
Summary
Prior to surgery, a pharmacist will randomly assign participating patients to one of two
groups. One group will get an injection in the knee during surgery that contains medications
to limit pain and an antibiotic. A second group will get an injection in the knee during
surgery that contains the same pain medications and antibiotic along with a corticosteroid to
control inflammation. Corticosteroids are anti-inflammatory medications, not to be confused
with muscle-building anabolic steroids you may have heard about in the news. Each patient
will have an equal chance of being in either of the two groups. This study will test the
safety and efficacy of methylprednisolone acetate in the treatment of pain and inflammation
following total knee replacement.