Do Antidepressants Induce Metabolic Syndromes METADAP Study

• Status: Completed
• Trial end date: 2013-04-01
• Target enrollment: 0
• Participant gender: All

Summary

Since antidepressants and antipsychotics have common receptorial mechanisms of action (H1 antagonism, 5HT2 antagonism), the impact of antidepressants in terms of metabolic syndromes is a matter of concern.

The main objective of this study is to assess the differential impact of antidepressants in terms of weight gain and metabolic syndromes.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assistance Publique - Hôpitaux de Paris
• Collaborator: Institut National de la Santé Et de la Recherche Médicale, France
• Treatments: Antidepressive Agents; Antidepressive Agents, Tricyclic

Criteria

Inclusion Criteria:

• Age : 18-70

• Current major depressive episode (Major depressive disorder) based on the MINI interview

• HAM-D >18

• Requiring either antidepressant treatment, either ECT or r-TMS (as assessed by the clinician)

• Signed informed consent

Exclusion Criteria:

• Bipolar disorder (DSM-IV), Psychotic disorder (DSM-IV), Substance abuse or dependence (DSM-IV)

• Normothymic treatment

• Antipsychotic treatment