Diurnal Variation of Exogenous Peptides (GH Puls/Jurgita I)
Status:
Completed
Trial end date:
2011-12-01
Target enrollment:
Participant gender:
Summary
This is an exploratory trial with four cross-over arms measuring the pharmacokinetic and
pharmacodynamic profiles of growth hormone using two different modes of growth hormone
administration (subcutaneous infusion into the abdomen or subcutaneous bolus injection in the
thigh) in 8 adult male or female patients with growth hormone deficiency during interval
exercise or in supine rest. The order of dosing regimen within the groups and between the
groups will be randomised. All patients will go through four different treatment sessions:A/B
Single subcutaneous bolus injection, supine rest without/with interval exercise, sessions
C/D: Continuous subcutaneous infusion, supine rest without/with interval exercise.
Hypotheses: 1) There is day-to-day variation of exogenous growth hormone, 2)Concentration of
growth hormone decreases due to exercise compared to supine rest, 3)There is a circadian
variation in pharmacokinetics of exogenous growth hormone infused subcutaneously