Overview

Diuretic Treatment in Acute Heart Failure With Volume Overload Guided by Serial Spot Urine Sodium Assessment

Status:
Not yet recruiting

Trial end date:
2023-07-31

Target enrollment:

Participant gender:

Summary

This is a pragmatic, multicenter, interventional, parallel-arm, randomized, open-label trial to investigate whether a diuretic regimen, based on serial assessment of sodium concentration (UNa) on spot urine samples after diuretic administration and with low-threshold use of combination diuretic therapy, improves decongestion versus usual care in acute heart failure (AHF), potentially leading to better clinical outcomes.

Phase:

Phase 4

Details

Lead Sponsor:

Vrije Universiteit Brussel

Collaborators:

Jessa Hospital
Roche Diagnostics

Treatments:

Acetazolamide
Bumetanide
Chlorthalidone
Diuretics
Sodium Potassium Chloride Symporter Inhibitors