Diuretic Response in Advanced Heart Failure: Bolus Intermittent vs Continuous INfusion
Status:
Completed
Trial end date:
2017-12-22
Target enrollment:
Participant gender:
Summary
Loop diuretics are the main therapy for decongestion of patients with advanced acute heart
failure. However, these patients often develop diuretic-resistance or even
diuretic-refractoriness. In order to overcome such resistance to diuretic, the clinician can
increase the dose of furosemide, or change the way of administration (continuous infusion
versus boluses) or associate a different class of diuretics (thiazide diuretics, K+-sparing
diuretics) up to the addition of low doses of inotropic agents to improve renal perfusion. At
the present time there is no evidence in literature in advanced acute heart failure patients
about the superiority of the treatment with furosemide in continuous infusion or in
intermittent boluses. The aim of the study was to evaluate the efficacy of furosemide in
boluses versus continuous infusion in advanced acute heart failure.