Disulfiram for Treating Cocaine Dependence in Individuals Maintained on Methadone

• Status: Completed
• Trial end date: 2007-01-01
• Target enrollment: 0
• Participant gender: All

Summary

Cocaine is an extremely addictive stimulant drug that directly affects the brain. It is used in several different forms and can be snorted, smoked, or injected to achieve the desired effect. Cocaine users are at risk for many health problems, both directly and indirectly related to the effects of cocaine. Disulfiram, a drug used to treat chronic alcoholism, may be effective in reducing cocaine use. This study will evaluate the effectiveness of three different doses of disulfiram in treating cocaine dependence in opioid- and cocaine-dependent individuals maintained on methadone.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Arkansas
• Collaborator: Yale University
• Treatments: Cocaine; Disulfiram; Methadone

Criteria

Inclusion Criteria:

• History of cocaine use at least once a week during the month prior to study entry

• Urine screen tests positive for cocaine

• Meets DSM-IV criteria for opioid- and cocaine-dependence

• Urine toxicology screen tests negative for benzodiazepines prior to beginning methadone treatment

Exclusion Criteria:

• Current drug or alcohol dependence other than opiates, cocaine, or tobacco

• Significant medical condition, such as abnormal liver function (with laboratory findings greater than three times normal), active hepatitis, or high blood pressure

• Current cardiac condition

• Occult coronary artery disease

• At high risk for cardiovascular disease, seizure disorders, or any other significant underlying medical condition that may make treatment with disulfiram or methadone unsafe

• Meets DSM-IV psychiatric diagnostic criteria for lifetime schizophrenia, bipolar disorder, or other psychotic disorders

• Currently suicidal or homicidal

• Currently taking a prescribed psychotropic medication that cannot be discontinued

• Pregnant

• Currently taking metronidazole or clotrimazole