Directed Immuno Nutrition by L-arginine for Critically Ill Patients

• Status: Completed
• Trial end date: 2011-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The main objective of this proof-of-concept study is to demonstrate that the only administration of L-arginine, based on a suspected deficit monitored by nasal nitric oxide measurement, can improve immune functions in critically ill patients at high risk of nosocomial infection.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assistance Publique - Hôpitaux de Paris

Criteria

Inclusion criteria :

• age > 18 years

• medical patient (absence of recent surgery or trauma)

• initial aggression < 5 days

• mechanically ventilated with expected duration of mechanical ventilation > 2 days

• enteral nutrition

• absence of previous immunosuppression

• nasal NO on day 1 of ICU stay < 60 ppb

Exclusion criteria :

• severe sepsis

• septic shock

• condition associated with a decreased nasal NO concentration (cystic fibrosis, nasal polyposis, primary ciliary dyskinesia

• pregnancy