Overview

Diphenhydramine as an Adjunctive Sedative in Patients on Chronic Opioids

Status:
Completed
Trial end date:
2018-07-01
Target enrollment:
0
Participant gender:
All
Summary
To access the efficacy of adding diphenhydramine as adjunct to improve sedation and to reduce the amount of standard sedatives used during colonoscopy in patients on chronic opioids.
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
University of Oklahoma
Treatments:
Diphenhydramine
Hypnotics and Sedatives
Promethazine
Criteria
Inclusion Criteria:

- Patients aged 18-64 years undergoing screening, surveillance, diagnostic and
therapeutic colonoscopy

- Patient on chronic opioids defined as at least 5 mg of morphine or its equivalent at
least 3 days per week for more than 3 months

Exclusion Criteria:

- Inability to execute informed consent

- Allergy to Diphenhydramine, fentanyl or midazolam

- Known or suspected pregnancy

- Endoscopic procedure without sedation

- Patient scheduled to have other endoscopic procedures on the same day

- Prior alimentary tract surgery

- Severe cardiopulmonary disease (ASA IV)

- Monoamine Oxidase Inhibitors (MOI) use within 2 weeks of procedure