Dimethyl Fumarate, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme
Status:
Completed
Trial end date:
2017-11-09
Target enrollment:
Participant gender:
Summary
This phase 1 trial studies the side effects and best dose of dimethyl fumarate when given
together with temozolomide and radiation therapy(RT) in treating patients with newly
diagnosed glioblastoma multiforme (GBM). Dimethyl fumarate may help radiation therapy work
better by making tumor cells more sensitive to the radiation therapy. Drugs used in
chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells,
either by killing the cells, by stopping them from dividing, or by stopping them from
spreading. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors.
Giving dimethyl fumarate with temozolomide and radiation therapy may work better in treating
glioblastoma multiforme.