Dilutional Coagulopathy in Patients Undergoing Elective Surgery
Status:
Completed
Trial end date:
2008-04-01
Target enrollment:
Participant gender:
Summary
The purpose of the present study is to perform a comprehensive description of haemostasis
parameters before and after haemodilution with Hydroxyethyl starch (HES) following acute
bleeding during elective surgery. Moreover the study aims to test the in vivo haemostatic
potential of fibrinogen concentrate in dilutional coagulopathy caused by HES in a clinical,
prospective, placebo-controlled randomised setup.
We hypothesise; a) A coagulopathy is induced following in vivo haemodilution; b) the
coagulopathy is improved or partially improved by fibrinogen.